About Help FAQ

Symbol
Name
ID

Aire
autoimmune regulator
MGI:1338803

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Asplenia
Disease(s) Associated with AIRE	Asplenia
autoimmune polyendocrine syndrome type 1

Mouse Phenotypes

increased T cell proliferation

abnormal thymus morphology

absent Hassall's corpuscle

abnormal thymus medulla morphology

thymus atrophy

abnormal thymus physiology

enlarged spleen

increased spleen weight

abnormal definitive hematopoiesis

abnormal myelopoiesis

decreased dendritic cell number

increased dendritic cell number

decreased follicular B cell number

increased marginal zone B cell number

increased B cell number

decreased regulatory T cell number

increased T cell number

increased monocyte cell number

abnormal T cell morphology

abnormal metallophilic macrophage morphology

abnormal spleen marginal zone morphology

abnormal CD4-positive, alpha-beta T cell physiology

abnormal T-helper 1 physiology

abnormal T-helper 17 cell physiology

abnormal T cell activation

abnormal regulatory T cell physiology

Availability

Mouse Genotype

Aire^{tm1.1(cre)Ghr}/Aire^{tm1.1(cre)Ghr}

Aire^{tm1.1(NCOM)Mfgc}/Aire^{tm1.1(NCOM)Mfgc}

Aire^tm1.1Doi/Aire^tm1.1Doi

Aire^tm1Pltn/Aire^tm1Pltn

Aire^tm1Ptsn/Aire^tm1Ptsn

Aire^tm2Mmat/Aire^tm2Mmat

Aire^tm1Mand/Aire⁺

Aire^tm1Mand/Aire^tm1.1Doi

Aire^tm1Mmat/Aire^tm2Mmat

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23